Exchange the gene studies of the sense and obtain the break-through in Chinese pancreas cancer

Exchange the gene studies of the sense and obtain the break-through in Chinese pancreas cancer
Exchange the gene studies of the sense and obtain the great breakthrough in forest east Xin, pancreas cancer which Professor Wang ChengFeng heads of institute of oncology of tumour hospital of Chinese Academy of Medical Sciences. In order to expound the inherent reason development takes place in pancreas cancer, look for the biological mark measured and diagnosed in early days, Lin DongXin and Wang ChengFeng's close cooperation, and unite Central China University of Science and Technology, the Fudan University, Chinese Medical Sciences University, second army medical university,etc. domestic unit 21, 25 hospitals of 16 provinces and cities have raised 3584 cases of pancreas a cancer patient and 4868 cases of normal contrast in the whole country, through the related research tactics of the whole genome, determine that appears in 5 new hereditary areas correlated to pancreas cancer or exchanges the sense allele. This the intersection of sample and the intersection of quantity and most large about exchanging sense gene in pancreas cancer many centre, clinic and research that foundation combine together in the world up until now. In this large-scale research, researchers carry on the mutant heredity of the whole genome and is concerned with analysis with 981 pancreas cancer patients and 1991 pieces of genome DNA contrasted normally at first, and prove in 2603 pancreas cancer patients and 2877 pieces of normal contrast in an independent one group, the ones that confirmed regional hereditary variation of 5 pieces of chromosome such as 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 led to the fact pancreas cancer takes place exchanged the sense factor. They find, the risk of pancreas cancer take place to the individuals who carries 5 dangerous genotypes 6 times higher than the individual not carrying the dangerous genotype. The result of study advanced the understanding that development mechanism takes place in pancreas cancer, offered the potential target to click for the prevention and treating of pancreas cancer at the same time, for the prevention, diagnosing that has established the sturdy theoretical foundation in early days of pancreas cancer of our country. Pancreas cancer malignant degrees of most high, the intersection of prognosis and most poor kind of tumour, survival rate is generally less than 5% in the patient's 5, it is qualified " King in cancer " . One of the main reasons why the cancer prognosis of pancreas is bad does not have effective early detection method, the diagnosing rate is smaller than 5% in early days; The best therapeutic method of pancreas cancer is that the surgery was excised, and most patients have already lost the chance of surgery treatment while seeking medical advice. This result of study is issued on the international top specialized periodical " natural science of heredity " online on December 11. This continues scientist another important achievement after entity's tumour research such as cancer of the esophagus, lung cancer and gastric carcinoma make progress of our country of this year. Lin DongXin the famous cause of disease of tumour in our country studies a researcher, the research respect achievement of cause of disease at malignant tumour such as pancreas cancer, lung cancer, gastric carcinoma, cancer of the esophagus is distinguished. Wang ChengFeng is a famous clinical medicine expert in our country, at belly tumour (internal organs tumours such as pancreas, biliary tract, intestines and stomach,etc.) Especially pancreas and gallbladder clinic, department of tumour make a diagnosis and give treatment and diagnosis, pancreas of cancer treat and relevant basic research field enjoy high reputation. (reporter Jia Jing)

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