It initiates the injury function of kidney that China analyses and explains and gathers cyanogen amine three times for the first time

It initiates the injury function of kidney that China analyses and explains and gathers cyanogen amine three times for the first time
Department of public health learns from Heilongjiang Province on the 22nd the reporter, a scientific research task finished recently by the expert of center for disease control of Heilongjiang Province, system announce, three gather the intersection of cyanogen and amine, initiate the intersection of animal and pathogenesis, the intersection of pathological change and characteristic, renal the intersection of crystalline solid and terms of forming that kidney damage for the first time at home and abroad. The result of study has d feed to three for the fact that the relevant department gathered cyanogen amine risk assessment, made three safety management limit magnitude of gathering the cyanogen amine in the food and feed to three fed. This achievement obtained the scientific and technological progress first prize of medical and health of Heilongjiang Province of 2009 recently. Three it gathers the intersection of cyanogen and amine to be food additive, domestic and foreign to gather the intersection of cyanogen and the intersection of amine and toxicity, study the materials, know to three very few, ey link,etc. that damage that kidney damage lack the deep discussion gather the intersection of cyanogen and amine, cause the intersection of quantity and the intersection of result and relation, crystalline solid and renal the intersection of pathology and issue of key link,etc. that damage that kidney damage lack the deep discussion to three too. In view of the above, set up and gather cyanogen amine and form big crystalline mouse's animal's model in the kidney three times in success for the first time such as chief physician of Heilongjiang Province institute for toxicology of center for disease control Wang YuYan, have reproduced the pathological change course of this disease. The method science of this model is advanced, there is repeatability. It is three poisonous function target organs which gather the cyanogen amine that the result of study announces the kidney. It is to gather cyanogen amine to catalyze in the stomach by the gastric acid hydrolyzing to turn into and gather cyanic acid three times three times that mechanism takes place in it, the two combine in the kidney again and form and gather cyanogen amine - gather cyanic acid and combine the crystal three times three times, crystal is full of renal tubules, make the renal volume increase, the weight increase, make the kidney organized seriously and ischemic because of pinching function of tube wall, cause the kidney to demonstrate the appearance of the characteristic color sandstone kind of colour of loess. It still shows to observe the result, it can also cause renal inflammation to react to organize pathology such as hyperplasia to change with the fiber to gather cyanogen amine crystalline solid three times, further initiate the renal supersession function obstacle, make content such as urea nitrogen, skin anhydride in blood increase, bring about renal failure in experimental animal finally. Wang YuYan,etc. adopts X ray diffraction law to confirm the crystalline solid formed in the kidney gathers cyanogen amine - three combination crystal which gather the cyanic acid three times for the first time under study for action, verify, ingest, three gather the intersection of cyanogen and amine, can make in the kidney forming, three gathering the intersection of cyanogen and amine - gather cyanic acid and combine the crystal 3 times, this means has innovative the obvious one. The expert opinion points out, this subject has filled in our country and gathered cyanogen amine toxicology and studied the blank three times, significant for preclinical medicine, pharmacy and clinical medicine. (the peak Lee beautiful cloud of dawn of clothing)

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