Chinese scientist finds the main inducement of gastric carcinoma: The protease receptor is lacked

Chinese scientist finds the main inducement of gastric carcinoma: The protease receptor is lacked
Bacterial infection, pressure, bad habits and customs It causes the mankind to suffer from gastric carcinoma that which on earth " The arch-criminal " ? On the 10th, the research institute of animal of Kunming of Chinese Academy of Sciences provides the answer according to the latest research results, should scientific research personnel make the new development in pathologic research field, member of gastric carcinoma, find it is a main reason for gastric carcinoma that a kind of protease is lacked by the body. China is the high taking place area of gastric carcinoma, find about 400,000 gastric carcinoma patients newly every year, accounts for about 40% of the number of the infected of gastric carcinoma in the world, gastric carcinoma patient's mortality is 4-8 times of the American-European developed country even more. Before this, the medical circle thinks unanimously, the spiral bacillus of pylorus is infected, the mood pressure in life, bad eating habit, such as being fond of baking, high salt, spicy food and getting drunk smokedly, will all destroy and damage the mucous membrane of stomach, cause diseases such as gastritis, gastric ulcer,etc., the ones that led to the fact gastric carcinoma takes place are risky. But the concrete reason is not clear. Animal researcher of research institute Zhang Yun and scientific research personnel such as Zhang Yong, Dr. Yu GuoYu,etc. in Kunming of Chinese Academy of Sciences discover, protease activates the receptor 4 (PAR4 receptor) Express in the intersection of stomach and mucous membrane extensively, it mucous membrane protect and damage, repair and gastric carcinoma have positive role take place, in stomach. Scientific research personnel further cooperate with first affiliated hospital of Kunming medical college, adopted molecular biology, cell biology and clinical pathology and studied the stomach mucous membrane of scientific discovery and damaged and repaired " The intermediary " --The significance decline among the gastric carcinoma patients of PAR4 receptor, it lacks and correlates with shifting, low intensity of splitting up of lymph node of gastric carcinoma; Ultra methyl of genetic promoter region of PAR4 receptor causes this receptor to express the main reason lacked, announce bad habits and customs and important pathogenic inducements in gastric carcinoma takes place such as the environmental factor,etc.. Scientific research personnel say, the above-mentioned result, in order to analyze the pathologic mechanism of physiology that people's stomach mucous membrane was protected, damaged and repaired and gastric carcinoma happened to offer new visual angle and clue thoroughly, also offered new possibility for the fact that pathologic process and prognosis of clinical gastric carcinoma are measured. (reporter Yang Yang one is firm)

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