Chinese scientist finds that can remove the protein molecule of pathogenic microbe

Chinese scientist finds that can remove the protein molecule of pathogenic microbe
A new " natural immunology " magazine published has been published to the chief of the office of national key experiment of my medical immunology, scientific findings of the second army medical university amynologic chief of research institute academician Cao XueTao research group. They have found an albumen molecule known as Lrrfip1 for the first time, can discern the invading pathogenic microbe DNA and RNA in immune cells, and then produce interferon through rotating and leading the thorough fare to activate immune cells in a kind of non- classical signal in order to remove the pathogenic microbe rapidly. This magazine allots the thematic comment, think research this know for people how resist mechanism that pathogenic microbe infect and resist infection immune system immune design of medicine propose Singapore side to thoroughly. Scientific research shows, once original microorganism of pathogenic venereal diseases such as the virus, bacterium,etc. invade the organism, the immune system will start and resist infection rapidly the immunity is replied and reacted. But the question of perplexing the immune educational circles for a long time is, through what kind of cell is the organism immune system distinguished " oneself " with the molecular mechanism With " not me " ,Thus the specificity perceives the original microorganism of venereal disease of other source to invade, and how to start the immunity effectively to reply the effect in order to wound, remove the pathogenic microbe. Last October, XueTao Cao at the invitation of " natural immunology ", write immune cell discern the intersection of pathogenic microbe and DNA in order to induce the intersection of Model I and the intersection of molecular mechanism and research comment that interferon produce, study the focus after putting forward 6 respects that this field appears at present. Lrrfip1 found this time can be discerned and combined the pathogenic microbe double-stranded DNA and double-stranded RNA directly, combine and activate a signal molecule, the key transcription factor and then produced through combining interferon of Model me subsequently, promote transferase P300 of acetylation to start the sub district to assemble in interferon, forms a interferon gene expression and strengthens three phases and compounds the body, thus promote interferon to produce. It's time to discover one are different from classical mode, discern from the kernel acid of afterbirth the member Lrrfip1 and immunity which downstream the intersection of signal and member makes up discern the pathogenic microbe core is sour and touching off the new molecule route that interferon of Model I produces, in order to resist infection the design of the medicine has offered new some targets and thinking. (reporter Tang XianWu)

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