Zhongshan University finds I g A nephropathy new exchanging the sense gene

Zhongshan University finds I g A nephropathy new exchanging the sense gene
Zhongshan University attaches to the first hospital to release the important research results of IgA nephropathy on the 8th - -Have found IgA nephropathy new exchanging the sense gene in the study on Asian experimenter. Zhongshan University attaches to first I of kidney internal medicine department of hospital and learns clearly to teach and lead more than 20 hospitals and research institutionses in group the United Nations of scientific research, and cooperate with Singaporean expert and finish exchanging the sense gene to sift, check that studies on the basis of the whole genome of the crowd IgA nephropathy of the Han nationality. Yu XueQing introduces, IgA nephropathy is the most common primary glomerulus disease in the world, the proportion accounting for the primary glomerulus disease in Asian-Pacific area is up to 40%-50%. Disease this whether relying mainly on IgA or IgA immunoglobulin (Ig) deposit in glomerulus, the intersection of glomerulus and the intersection of department and the intersection of membrane and the intersection of cell and hyperplasia, and the ground substance is gathered as the main characteristic outside the cell. According to the present materials, there is final development of the patients of 15%-40% to latter stage of end kidney trouble (uremia) . Discover, IgA nephropathy has obvious families to gather inclination, is listed in genetic hereditary disease category more. IgA nephropathy has illness coming on and hides, diagnose and it is significant to delaying the renal function and worsening to treat in early days. Yu XueQing introduces, this research is that it is analysed and researched that the whole genome of Asia of the biggest sample is related up until now, include more than 10,000 experimenters (4137 IgA nephropathy patient and 7734 healthy crowds) ,Utilize advanced analytical method of science of heredity and tactics, carry on research at the whole genome level. "Researchers have already verified some results of study of the American-European scholar's, the more important thing is that has found the unique Liang of new exchanging the gene location of the sense to click of IgA nephropathy in the Chinese crowd for the first time - -On chromosome and the 8th chromosome of the 17th, proved the inherent cause plays an important role in the morbidity mechanism of IgA nephropathy, and can influence morbidity course and clinical manifestation of IgA nephropathy. " He says, because of the genetic difference, the clinical manifestation of IgA nephropathy is widely different, there is morbidity of offspring in families of history of chronic kidney trouble and first class relative, be higher than the family without history of this disease. (reporter Xiao SiSi)

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