China's leukemia is studied made the great breakthrough

China's leukemia is studied, made the great breakthrough
Cable of April 9 of Shanghai of China News Service (reporter Chen Jing) The reporter learns today, the subsidiary haematological scientists of research institute of Shanghai of Rui Jin hospital of Shanghai Communications University medical college find the cancer albumen PML-RAR is that arsenical treat APL - -Acute for a long time the young direct medicine target of grains of cellulous leukemia has been clicked, has removed direct member's target some and molecule mechanism difficult problem of perplexing Chinese and foreign scientists for a long time. The 9th, the international authoritative magazine " science " (Science) Have issued the above-mentioned great achievement: Oxidize two arsenic treatments and acute young grains of cellulous leukemia (APL) for a long time three times The latest research results of the molecular mechanism. The expert points out, theory to the treatment of this fruitful APL target, target study, have very much important directive significance to treat for promote other type of leukemia and molecule, entity of tumour. It is reported, APL is the acute marrow cellulous leukemia of a kind of special type, were once considered to be one of the most critical leukemia, PML-RAR cancer albumen with characteristic nature. Lack therapeutic method effectively, a lot of patient have illness coming on, die from, bleed seriously promptly early period once. 1985, Shanghai blood grind king shake the intersection of justice and Professor take the lead in, employ, it links first against type to be sour (ATRA) all in the world Treat APL patient and succeed, more than 80% of the patients can totally relieve, but the short-term content is apt to recur. In the 1990s of last century, on the basis of APL patient makes curative effect to employ the traditional Chinese medicine and oxidize two arsenic three times and treating, Shanghai blood grind the intersection of expert and Zhu Chen, have a match beautiful, oxidize, succeed in, treat, link, able to bear APL patient that medicine recured by first acid with three against type all by two arsenic while being old, and it induces the leukaemia cell to split up and wither in the double pharmacology mechanism of dying to find arsenical. But it is problems of perplexing the whole world researchers to oxidize direct molecule target some and molecule mechanism of two arsenic three times for a long time. For this reason, Chen Zhu, having a match oldly beautifully to once propose, the probably direct target of arsenical was to PML-RAR cancer albumen at first, produce the specificity and treat function. In latest research results, scientist find, three oxidize two the intersection of arsenic and direct and cancer end, PML of albumen, " zinc is referred to " Cysteine in the structure is combined, induce protein to be degraded by the body of protease. The degradation of the cancer albumen causes the leukaemia cell to move towards splitting up and withering and dying finally, make APL become human acute target, member of leukemia, to treat, make the clinical successful example that cures. Expert say research results this explain, three oxidize two the intersection of arsenic and curing APL the intersection of medicine and the intersection of molecule and some target and molecular mechanism not merely, more far-reaching meaning has lain in offering the basis of theory and practice for treatment new tactics of tumour. The expert points out, arsenical is an old traditional Chinese medicine with 2000 histories of more than years, announce the molecule function mechanism of traditional Chinese medicine by means of modern science, will promote the Chinese scientist to further investigate and excavate the traditional medical treasure-house of the motherland. It is reported, this research grinds the scientific research team of the three generations of the the aged,middle aged person and young man as the core with blood of Shanghai, many scientific research institutions jointly tackle key problems after uniting both at home and abroad. The biochemical cells of academy of sciences of Shanghai life of the Chinese Academy of Sciences that these organizations include, with the medicine, the research institute of high-energy physics of Chinese Academy of Sciences, the academy of sciences of China's scientific and technical university student's life, the intersection of Hefei and country radiate laboratory synchronously, Chinese Academy of Sciences animal, Sino-French life sciences and genome research center, many unit seminars such as the seventh university in Paris of France. (End)

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