Why do some lung cancer patients take the target to the medicine invalid

Why do some lung cancer patients take the target to the medicine invalid
It is reported ' Reporter river fly to boat Cao Zheng, reporter of Li Hao) Guangdong Province the intersection of the People's Hospital and the intersection of tumour and the intersection of centre and Qing, dragon Wu Zhou,etc. discover, lung cancer target is not only correlated with having gene mutation, is but also closely linked to quantity of gene mutation to the curative effect of medicine. This research puts forward the concept from target to result relation of the medicine amount for the first time in the world, the intersection of lung cancer and effective perfect individualization treat tactics, get new studying the direction out of to future. The relevant thesis is issued in the oncological magazine " clinical oncological magazine " of world authority recently. According to one dragon introduction Wu, medical circle think, accord with women, smoke, the intersection of gland and the intersection of cancer and 3 lung cancer patient of factor these generally before the this, use these triumphant 2 kinds of molecule targets of apt auspicious sand or special Luo to the medicine, it can reach 60% to treat efficiently. Scientific research is found, gene mutation is a key factor among them, if detect EGFR (epidermis growth factor receptor) The lung cancer patient of sudden change, take these 2 kinds of molecule targets to the medicine, it can reach 70%~80% to treat efficiently, the patient had already survived from 3 to 5 in a lot of later period, it is the 7 years longest. But, why 20%~30% of the lung cancer patients find obviously that there is gene mutation, but take medicine invalid or fail after taking short time? For this reason, it perhaps has hypothesis sure to concern to the curative effect of medicine with the lung cancer target that researchers have got EGFR sudden change quantity out of, utilize the existing method to measure different characteristics of EGFR sudden change sensitiveness, has designed relevant research. The result conclusion of clear quantity must happen finally in this research: The target of patient that sudden change quantity high is the best to the curative effect of medicine, the result of patient that sudden change quantity is low is relatively bad, there is not the coming to naught of sudden change. Therefore, researchers draw the conclusion to think, lung cancer target is not merely correlated with having gene mutation to the curative effect of medicine, still closely linked to quantity of gene mutation.

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