The academician of Zhongshan University decodes " Cancer in Guangdong " Exchange the sense gene

The academician of Zhongshan University decodes " Cancer in Guangdong " Exchange the sense gene
The Guangdong scientist unites the domestic and foreign expert, has found distributing 3 new exchanging the genetic location of the sense to click of nasopharyngeal carcinoma, fully confirmed the antigen of human leucocyte (HLA) at the same time Relevance of the risk that gene and nasopharyngeal carcinoma have illness coming on. And expected to develop, predict nasopharyngeal carcinoma have illness coming on genetic chip of the risk within 5 years, thus improve the examining rate early, lower mortality greatly. Zhongshan University the intersection of tumour and the intersection of centre of prevention and cure and director, Chinese Academy of Sciences academician benefit introduce newly once, the scientific research group that he led cooperates with Singaporean genome Dr. Liu Jianjun of research center, through the efforts of 5 years, exchange the sense gene to sift, check that studies after finishing distributing nasopharyngeal carcinoma based on large-scale crowd and the whole genome level for the first time. They carry on the contrast of dividing into groups to more than 5000 nasopharyngeal carcinoma patients and more than 5000 healthy persons from South China, find the antigen of human leucocyte (as the protein complex of cell membrane, it is the most basic component of the human immune system) With other three genes (TNFRSF19, MDSI-EVI1 and CDKN2A/2B) It is exchanging the sense gene of nasopharyngeal carcinoma, can influence the morbidity risk of nasopharyngeal carcinoma notably. In addition, seeing that these exchange sense gene and all correlate with leukemia, the morbidity mechanisms of nasopharyngeal carcinoma and leukemia may have similar mechanism. This achievement was released in the international top magazine " natural science of heredity " (NatureGenetics) yesterday . This great scientific findings have special meaning on Guangdong. Zeng YiXin says, nasopharyngeal carcinoma is to occur frequently on the nasopharyngeal top and swallow malignant tumour in the latent nest, the onset has local characteristics. Our country is the country of nasopharyngeal carcinoma with highest morbidity in the world, and South China, especially Guangdong and closing on in area such as Guangxi and Hong Kong and other places is the high having illness coming on area, morbidity, than most other country, the intersection of area and high more than 100 times, so nasopharyngeal carcinoma has " cancer in Guangdong " too It claims. And distributing nasopharyngeal carcinoma accounts for 90% of the number of the infected of nasopharyngeal carcinoma. This research makes the scientist stride forward a great step in the process that expounded the pathogenesis of science of heredity of nasopharyngeal carcinoma finally, for develop, predict nasopharyngeal carcinoma have illness coming on genetic chip of risk and improve nasopharyngeal carcinoma examining rate laid the foundation early. The reporter learns in addition, the money of centre of prevention and cure of Zhongshan University's tumour jointly proposed a kind of science hypothesis towards south doctor and state-run Deputy Director JosehpWee of cancer centre of Singapore recently - --" whether world most nasopharyngeal carcinoma originate from getting ancient tribe, South China of China, " . Hypothesis this think nasopharyngeal carcinoma exchange the intersection of sense and gene until " whether one hundred " Regional women carry, are married and introduced to Guangdong, east African, Arabic, and migrate from different routes to Southeast Asia, Oceania, Bering area, these genes are spread, cause the phenomenon of the high hair of these areas. Zeng YiXin says, this newest scientific findings of theirs have " support partly " on this hypothesis ,But still lack more overall crowd's evidence, remaining to further study verifies or overthrows. (reporter / the intersection of Chinese sweet gum and reporter / gold beautiful Chen �] Chen)

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