China discover silver the intersection of bits and pathogenic arch-criminal of disease Offer the target for therapeutic method to click

China discover silver the intersection of bits and pathogenic arch-criminal of disease Offer the target for therapeutic method to click
Yesterday, Shanghai Communications University medical college subsidiary Rui Jin hospital announced, obtained important progress in the disease research field of the silver bits: Have found silverly that considers the disease to be worth doing that causes a disease " The arch-criminal " --Lie in the �æ� T lymphocytes in dermis. Research this make by the intersection of Rui Jin and the intersection of hospital and dept. of dermatology and the intersection of university and the intersection of medical college and immunity, tumour and biological the intersection of medical center and Yan Jun subject of Professor, Louisville of U.S.A., up and make, regard young doctor Cai YiHua, Shen XiaoYan of dept. of dermatology of Rui Jin hospital as first and the second author's thesis " Dermis �æ� T cells are the main production cells of inflammation dermatosis IL-17 " Issue in the latest " immunity " magazine (influence the factor 24.221) . The silver bits are ill, commonly called as " psoriasis " ,Has already become disease endangering human health seriously, among them pustule type and red cover are ill type,etc. the type is serious, even jeopardize the life; It can cause the joint deformity, disable the most serious one in all arthritis that the joint is ill type. According to the statistics of little sample of the last time, the disease morbidity of silver bits of our country is up to 1%. The helpless one is, because of the mechanism of failing to have illness coming on clearly, the whole world does not have effective treatment means to the silver bits yet while being ill, the patient often recurs after symptom is relieved, and the condition becomes more serious while recuring. The credit of venereal disease of skin of Chinese Medical Association is known Vice Chairman, Rui Jin hospital skin head of the department, this article communication author Professor Zheng Jie and introduced, the intersection of research of them and attention to cause international medical circle, verify, lead to the fact silver the intersection of bits and whom disease take place lie between plain 17 (IL-17) in vain for the first time Ones that were not once thought over a long time, coming from Th17 cells in the blood circulation, but cell, T of �æ�, to come from dermis, lie between plain 23 (IL-23) in vain Stimulus under,if you can't produce in a large amount, lead to the fact whether it is silver bits IL-17 where the diseases take place. This result of study, not merely to silver the intersection of bits and disease, it has enlightenment too that the cause of disease to other organ diseases learns to study. Study, find Toll kinds of difference of receptor mix the body (various pathogen wait) at the same time Can make �æ� T cells produce more IL-17 in coordination with IL-23 in varying degrees. Because relate to the Nobel Prize issued newly, " Toll one kind of receptors " Being paid close attention to by people day by day. It is a kind of protein in the human body in fact, when the bacterium invades, can activate the congenital immunoreaction of the human body fast, start " line of defence of the health " . The research group of Rui Jin hospital explains, find that studies the disease pathogenesis of silver bits in order to deepen this time, especially streptococcus, when pathogen is infected, how cause natural immune system produce pathology immunity replied, have offered very good breakthrough point. As to patient, this research or influencing therapeutic method. Because cure the method effectively " The omission " ,It is in the treatment that the silver bits are ill that domestic " the Eight Immortals crosses the sea, each shows his special skill " State,it is treat extremely urgent not to last norm. Jie Zheng introduce, the intersection of president and issue this insist " rely mainly on the fact that to skin treatment, object to too much systematic administration " Opinion treatment silver for bits disease,last clinic controlling rates better already. On the international medical circle, the deep meaning of this research still lies in: Or the one that has offered medicine function for developing the pointed treatment medicine in the future " The target is clicked " . (reporter Tang WenJia)

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