Acetylation is decorated: " little role " There are great uses

Acetylation is decorated: " little role " There are great uses
It is reported ' Reporter Sun GuoGen) February 19, international authoritative periodical " science " that publish newly issue the intersection of Fudan University and biomedical the intersection of research institute and generation the intersection of the people and Professor and two theses of Professor,etc., heroes of thunder, Zhao at the same time, their research results have announced the material base of the life - -New mechanism of acetylation of protein. Science is specially entitled as " utilizing and supersession that acetylation of supersession enzyme coordinate carbon source " for these two the thesis of and " acetylation of protein 2,6-diaminocaproic acid is adjusted and controlled " mix Page two -long professional comment, think " this research has offered the new thinking for developing research of adjusting and controlling the supersession medicine ", it is possible to offer for development of the brand-new treatment means of disease including leukemia, tumour " . What is meant by " acetylation is decorated " ? Scientific circles had thought it was in the past " The little role " . According to generation the intersection of the people and Professor and Professor of thunder heroes introduction Zhao, the human body can be compared to a " battle field " ,The gene is the key organization commanding the life to operate, cells are maintaining the basic function of the human body, but cells carry out every complicated task by protein mainly, protein is the soldier pitching into the work directly in the life moves. " bare-handed " Protein acetyl " The arms " Can become the soldier fighting for the human body after standing up. Conduct to signal, energy supersession,etc. different " The battle field " ,Protein needs to allocate different one " The weaponry " ,Could play a different role, extend body function. Protein carries out different tasks to need to carry on different one " Make a variation " ,Once protein is grafted one and called " acetyl group " Molecule,it quilt decoration acetylation protein. Have dozens of even the intersection of more than one hundred and decoration in the human body, for example phosphorylation modify and methyl modify, it is one of them that acetylation is decorated. The mankind has already had a history of 40 years to the research that acetylation decorated, however, the understanding of it of scientific circles has gone through the long and arduous road, so this research has been stagnating all the time, its main reason and acetylation protein are more obscure, more difficult to be been discovered and have something to do with. And Zhao ShiMin, thunder heroes study the group under the circumstances that this courtyard of bears jumps, are in charge of two good famous professors femaly to lead, study in the supersession thorough fares of protein research and different species through the flux, have succeeded in finding acetylation protein of a large number of non- nucleus. Before this research is launched, the scientist only finds that there are 76 acetylation proteins in human liver cells, their research has already found over 1000 acetylation proteins nowadays. It verifies, in disease correlated to mankind, 80% relate to the fact that the supersession is out-of-balance to have something to do and study, among them tumour is the most important supersession disease. The above-mentioned research can help the scientist through adjusting and controlling acetylation, thus adjust the speed of the supersession, let some beneficial supersession let some unfavorable supersession be a bit slower, for example let tumour not grow up even diminish a bit faster, then mean adjusting and controlling disease. Thesis first author ShiMin Zhao claim meaning of discovery of them lie in, find acetylation to be general to modify the function to the intersection of supersession and enzyme, this has offered important basis and brand-new thinking for the fact that the medicine of supersession disease is researched and developed. However, as to the thing that when the medicine will emerge, Zhao ShiMin and his research group say, perhaps there are very long waysing will go. Because acetylating protein has very high specificities, the acetylation proteins of different diseases are different, just like target, it is not clear to click the target, adjustment has no way of doing it, and one degree of good assurance that adjusts and controls. Zhao ShiMin says at the same time: "Each studies several hundred of the new discovery, even more acetylation albumen and their characteristic will be studied especially in the future. "

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