The endocrine treatment of breast cancer is able to bear the medicine mechanism there are new statements

The endocrine treatment of breast cancer is able to bear the medicine mechanism there are new statements
It is reported recently, military the intersection of academy of medical sciences and the intersection of protein and group study national key the intersection of laboratory and piece, study quick seminar and the intersection of PLA and the intersection of general hospital and Wei, set up new subject to make up and make, in the endocrine of breast cancer is therapeutic makes important progress when able to bear mechanism's research of medicine. Find inflammation adjust and control molecule CUEDC2 in the intersection of breast cancer and cell excessive to express, cause some the intersection of breast cancer and patient treat, produce, able to bear medicine to endocrine, have announced CUEDC2 brings out the brand-new molecular mechanism able to bear medicine. The relevant research thesis is issued in the academic periodical " natural medical science " of the international authority online on May 16. It is malignant tumour on estrogen reliance because of most breast cancer, so the endocrine treatment becomes one of the important means. Not the west of his is fragrant to employ the most extensive therapeutic medicine of breast cancer endocrine at present, but it is one of the main reasons causing the clinical treatment of breast cancer to fail to be able to bear the medicine question. Piece study quick seminar find CUEDC2 protein can specificity combine the intersection of estrogen and receptor in previous research ,And cause ER to degrade. On this basis, the immune group of breast tissue analyzes through clinical breast cancer and cancer to the big sample, find in breast cancer unusually high to express protein this, express competence appear prominent defeat relevant with ER. Pass and recur and survive and follow up a case by regular visits to the retrospect of the data to analyze in 5 years - 10 years about this part of patients, find the expression level of CUEDC2 and the breast cancer patient's close relation of prognosis. High breast cancer patient that expresses is able to bear medicines to his not west Finland's treatment with this protein, the low patient that expresses treats and can survive for a long time through his not west Finland. They step forward at cell and animal's level, have announced CUEDC2 expresses degrading and resulting in being able to bear the molecular mechanism of medicine through promoting ER high, prove this protein is a new causing the breast cancer patient to be able to bear the important molecule of medicine to the endocrine treatment. (king happy Shen's base flies)

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