China takes the lead in succeeding in developing oral administration and recombinating spiral shell's bacillus vaccine of pylorus

China takes the lead in succeeding in developing oral administration and recombinating spiral shell's bacillus vaccine of pylorus
Entrust Liu to defeat the river in the king Not long ago, the Ministry of Science and Technology held the news briefing and announced in Beijing: China takes the lead in succeeding in developing the oral administration with totally independent intellectual property right and recombinating spiral shell's bacillus vaccine of pylorus, this vaccine has already obtained national food medicines and supervised a kind of new medicine certificate of country that the administration bureau sanctioned being awarded. This project chief scientist, third army medical university Professor Zou QuanMing are filled with all sorts of feelings in the news briefing live: "For a kind of new medicine in 15 years, it is not very long. But the hardships very much of the course, nearly came into the blind alley sometimes. " Set up: Fire and protect " The stomach " Fought in 1983, fertile logical sequence of Marshall and Robin found spiral shell's bacillus of pylorus (Hp) in Australian scientist bar . It is verified that two scientists study, Hp lives away from home in the bacterium of people's stomach mucous membrane, it is mainly causing the son of cause of disease of many kinds of upper digestive tract diseases such as gastritis, gastric ulcer, duodenal ulcer. Many years ago, World Health Organization confirmed Hp as a kind of carcinogenic factor correlated to gastric carcinoma. Hp is one of the bacteria of supreme infection rate in the world at present. The infection rate of developing countries is above 50%, the infection rate of developed country is above 40%. Hp the infeted of our country exceed 600 million people, is much higher than the number of person who carries virus of hepatitis B alone. The statistics show, our country dies of the number of people about 200,000 of gastric carcinoma every year. Infect in order to deal with spiral shell's bacillus of pylorus, the mankind develops generation upon generation of antibiotic, but is fewer than 30% to the radical cure rate of stomach trouble. "Clinic mainly adopts many kinds of antibiotic to jointly treat, but Hp perches and occupies the position is a high acid environment, have weakened the medicine result seriously. " Zou QuanMing says, recurs and infects and becomes the clinical difficult problem being treated all the time again. "Vaccine inoculation is to prevent the most effective, most economic means of disease. " In 1995, subject for research of spiral shell's bacillus vaccine of the pylorus was set up, 32 -year-old Zou Quan would lead the seminar tomorrow, go to look for and prevent the most effective route that Hp infect. The hardships: Trying to find out " it is to try to find out " in every link. " Seminar member Professor Guo Gang introduces, research and develop the animal model must set up one Hp of vaccine. But feed the bacterium to the mouse, batches of mice are not infected with. The international conference that Guo Gang goes to Beijing to participate in a digestive tract disease, hear Australian scientist mention the Mongolian sand mouse is easy to infect. He searched in the whole country everywhere, found this kind of sand mouse in the medical experimental center of Zhejiang finally. The seminar spends 1000 yuan buying back 50 pieces of sand mouse, the first batch has not been infected, the second batch has not been infected, infection until the third batch had at last. Through after the repeated screening, going down to posterity many times of 5 years, they succeeded in setting up long and steady animal and infecting models. Vaccine researches and develops links more, spiral shell's bacillus vaccine of pylorus adopts the gene to recombinate the way, the purified craft of protein among them is very crucial. "Draw protein from Hp, protein purification, eight or nine people tackle key problems continuously, did not succeed until one year. " Seminar Professor Mao XuHu speaks of the scene that tackled key problems at that time, there is only a word, " people can endure more than the machine " . The purified system of protein works continuously in 24 hours, seminar members keep day and night and observe by the machine, the machine can not stand shutting down finally " The strike " ,XuHu and others Mao must make analysis. "By 10 years, the hair is black and white, but find pleasure in it. " Maos of the intersection of brilliance of the rising sun and tiger hey hey smile. Innovation: It is pregnant and raw to borrow the belly " Deep and remote" Spiral shell's bacillus of sub pylorus can produce a large number of urea enzyme, resists the gastric acid environment, the survival ability is very strong. What kind of vaccine can oppose it? Traditional vaccine adopt, reduce malicious deactivating waying, " but Hp may carcinogenic, such a way will bring hidden danger, can't totally remove toxicity " . 1999, get Germany make the visiting scholar's Zou QuanMing, visit a pharmaceutical factory, 10 multi-type genetic engineering medicines attracted him. After consulting a large amount of international academic literature, he proposes using the thinking for producing spiral shell's bacillus vaccine of pylorus of genetic engineering boldly. "Genetic vaccine has two major advantages, first, removable poisonous part, take out in bacteria the useful part is processed, such as adding adjuvant,etc., make it more effective; It is controlled second, high quality, extract qualities are stable, are free of condition of various of external world. " The cultivation cost of Hp is high, the cost of Escherichia coli is low, the seminar determines to put forward the gene of Hp, while marrying and receiving Escherichia coli, it is pregnant to borrow the belly to grow " deep and remote "ly Son. It is the injecting type that nowadays vaccine is adopted most, what spiral shell's bacillus vaccine of pylorus is taken at the beginning is this road too. But seminar personnel find after the experiment, vaccine stimulates most antibodies produced in blood, it is very difficult to reach the mucous membrane position of the stomach, the result is not obvious. If build a line of defence on the mucous membrane of stomach, does not Hp lose the passway bred? Just as open different locks with different keys, if you want to let the human body produce antibodies and should find the antigen first. But the genetic association of Hp is very complicated, there are as many as ten thousand genetic password, thousands of pieces of antigen, if you want to find out several kinds of antigen become effective compositions of vaccine, the difficulty is quite great. The seminar will look for the antigen to lock on this link of invading the mucous membrane of stomach in Hp. "If can let the mucous membrane of stomach produce secreting antibodies, can play a role in preventing Hp. " Oral vaccine mainly produces the mucous membrane antibody, but in the blood, need adjuvant to inspire in theory. Effective composition and effective composition of adjuvant of vaccine connect together, become an organic whole in member. The seminar initiates the mucous membrane vaccine theory of adjuvant in the molecule in the world, adopt the unique genetic engineering vaccine molecule to construct the mode, produce immunity, solve Hp, infect on the surface of mucous membrane and difficult problem different to prevent and cure in the intersection of mucous membrane and surface. Vaccine is absorbed through oral administration, easy and is destroyed but fail by sour liquid and various digestive ferment in the gastrointestinal tract. The seminar has used a new patented technology, adopt special craft dosage form, have overcome the gastric acid, peptic katogene to vaccine, has improved validity and stability of vaccine. Employ: It indicates, spiral shell's bacillus vaccine of pylorus has good security that all healthy crowds can take the clinical trial, it is 72.1% to prevent the protection rate that Hp infects. Who are suitable for taking spiral shell's bacillus vaccine of pylorus? Zou QuanMing says, all healthy crowds can take. The crowd infected by Hp can take spiral shell's bacillus vaccine of pylorus. Usually children are high infection crowds of Hp, advise children to take to the target for the focal point of spiral shell's bacillus vaccine of pylorus. As to already patient that Hp infect, can go ahead of the rest regular " 3 unite and treat " ,Eliminate internal Hp, then take vaccine and produce the protective antibody. Take vaccine once How long to manage? How high are the general expenses? Zou QuanMing says, after taking spiral shell's bacillus vaccine of pylorus once, immunity to Hp of the organism can be maintained in 4 - 5 years, if strengthened immunity once hereafter, prevent and cure one? ���� paces up and down in the cellar and reflects �� D shell dam �� and dismisses from the pepper Hu short wooden stake shin acute communicable diseases Pu cover �� distant Nuo? 000 yuan, and apt to recur, it is able to bear nature to emerge; And the cost which take spiral shell's bacillus vaccine of pylorus is reduced greatly, it is only 1/5- 1/3 of the traditional method.

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